John Perfect Shares Insights on Infectious Diseases, Antifungal Therapy, and Drug Resistance
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Abstract
In this engaging interview, Dr. John Perfect reflects on his distinguished career in infectious diseases, focusing on his early scientific interests, his pivotal experiences during the emergence of HIV/AIDS, and his extensive research on fungal pathogens, particularly Cryptococcus. Dr. Perfect discusses the evolution of antifungal therapies, the challenges of drug resistance, the promise of molecular diagnostics and immunotherapies, and the complexities faced in clinical research. He emphasizes the importance of mentorship and optimism for future generations of scientists, concluding with a message of hope and encouragement for ongoing innovation and resilience in medical science.
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References
1. Janbon G, Ormerod KL, Paulet D, Byrnes EJ, 3rd, Yadav V, Chatterjee G, Mullapudi N, Hon CC, Billmyre RB, Brunel F, Bahn YS, Chen W, Chen Y, Chow EW, Coppée JY, Floyd-Averette A, Gaillardin C, Gerik KJ, Goldberg J, Gonzalez-Hilarion S, Gujja S, Hamlin JL, Hsueh YP, Ianiri G, Jones S, Kodira CD, Kozubowski L, Lam W, Marra M, Mesner LD, Mieczkowski PA, Moyrand F, Nielsen K, Proux C, Rossignol T, Schein JE, Sun S, Wollschlaeger C, Wood IA, Zeng Q, Neuvéglise C, Newlon CS, Perfect JR, Lodge JK, Idnurm A, Stajich JE, Kronstad JW, Sanyal K, Heitman J, Fraser JA, Cuomo CA, Dietrich FS. Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. PLoS Genet. 2014;10(4):e1004261. doi: 10.1371/journal.pgen.1004261. PubMed PMID: 24743168; PMCID: PMC3990503.
2. Perfect JR. The antifungal pipeline: a reality check. Nat Rev Drug Discov. 2017;16(9):603-16. doi: 10.1038/nrd.2017.46. PubMed PMID: 28496146; PMCID: PMC5760994.
3. Kanafani ZA, Perfect JR. Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact. Clin Infect Dis. 2008;46(1):120-8. doi: 10.1086/524071. PubMed PMID: 18171227.
4. Alexander BD, Perfect JR. Antifungal resistance trends towards the year 2000. Implications for therapy and new approaches. Drugs. 1997;54(5):657-78. doi: 10.2165/00003495-199754050-00002. PubMed PMID: 9360056.5. Tseng HK, Perfect JR. Strategies to manage antifungal drug resistance. Expert Opin Pharmacother. 2011;12(2):241-56. doi: 10.1517/14656566.2010.517195. PubMed PMID: 21226635.
6. Notes from the Field: First Reported U.S. Cases of Tinea Caused by Trichophyton indotineae — New York City, December 2021–March 2023. Morbidity and Mortality Weekly. 2023 May 12, 2023:536–7.
7. Spivack S, Gold JAW, Lockhart SR, Anand P, Quilter LAS, Smith DJ, Bowen B, Gould JM, Eltokhy A, Gamal A, Retuerto M, McCormick TS, Ghannoum MA. Potential Sexual Transmission of Antifungal-Resistant Trichophyton indotineae. Emerg Infect Dis. 2024;30(4):807-9. doi: 10.3201/eid3004.240115. PubMed PMID: 38437706; PMCID: PMC10977831.
8. Pappas PG, Bustamante B, Ticona E, Hamill RJ, Johnson PC, Reboli A, Aberg J, Hasbun R, Hsu HH. Recombinant interferon- gamma 1b as adjunctive therapy for AIDS-related acute cryptococcal meningitis. J Infect Dis. 2004;189(12):2185-91. doi: 10.1086/420829. PubMed PMID: 15181565.
9. Jarvis JN, Meintjes G, Rebe K, Williams GN, Bicanic T, Williams A, Schutz C, Bekker LG, Wood R, Harrison TS. Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial. Aids. 2012;26(9):1105-13. doi: 10.1097/QAD.0b013e3283536a93. PubMed PMID: 22421244; PMCID: PMC3640254.
10. Perfect JR, Kronstad JW. Cryptococcal nutrient acquisition and pathogenesis: dining on the host. Microbiol Mol Biol Rev. 2025;89(1):e0001523. doi: 10.1128/mmbr.00015-23. PubMed PMID: 39927764; PMCID: PMC11948494.