Comments on “Early Activation of Lung CD8+ T Cells After Immunization with Live Plasmodium berghei Malaria Sporozites”
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Abstract
The recent study by van Schuijlenburg et al [1] suggests that the lungs may serve as an active and previously underappreciated site of T-cell priming following late-arresting genetically attenuated parasites (LA-GAP) malaria vaccination. Their findings channel traditional liver-focused models and open important avenues for understanding the immunological dynamics of whole-sporozoite vaccines.
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References
1. van Schuijlenburg R, Naar CM, van der Wees S, Chevalley-Maurel SC, Duszenko N, de Bes-Roeleveld HM, Iliopoulou E, Houlder EL, Geurten FJA, Baalbergen E, Roestenberg M, Franke-Fayard B. Early Activation of Lung CD8(+) T Cells After Immunization with Live Plasmodium berghei Malaria Sporozoites. Pathog Immun. 2025;10(2):46-68. doi: 10.20411/pai.v10i2.794. PubMed PMID: 40062354; PMCID: PMC11888604.
2. Metkar SS, Menaa C, Pardo J, Wang B, Wallich R, Freudenberg M, Kim S, Raja SM, Shi L, Simon MM, Froelich CJ. Human and mouse granzyme A induce a proinflammatory cytokine response. Immunity. 2008;29(5):720-33. doi: 10.1016/j.immuni.2008.08.014. PubMed PMID: 18951048.
3. Fernandez-Ruiz D, Ng WY, Holz LE, Ma JZ, Zaid A, Wong YC, Lau LS, Mollard V, Cozijnsen A, Collins N, Li J, Davey GM, Kato Y, Devi S, Skandari R, Pauley M, Manton JH, Godfrey DI, Braun A, Tay SS, Tan PS, Bowen DG, Koch-Nolte F, Rissiek B, Carbone FR, Crabb BS, Lahoud M, Cockburn IA, Mueller SN, Bertolino P, McFadden GI, Caminschi I, Heath WR. Liver-Resident Memory CD8(+) T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection. Immunity. 2016;45(4):889-902. doi: 10.1016/j.immuni.2016.08.011. PubMed PMID: 27692609.
4. Chakravarty S, Cockburn IA, Kuk S, Overstreet MG, Sacci JB, Zavala F. CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nat Med. 2007;13(9):1035-41. doi: 10.1038/nm1628. PubMed PMID: 17704784.