B-Cell Responses to Sars-Cov-2 mRNA Vaccines

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Published: Dec 9, 2022
DOI: https://doi.org/10.20411/pai.v7i2.550
Keywords:
SARS-CoV-2;, vaccination;, protective immunity;, B cells;, plasmablasts;, memory response;, antibodies

Main Article Content

Lela Kardava
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD
Clarisa M. Buckner
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD
Susan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD

Abstract

Most vaccines against viral pathogens protect through the acquisition of immunological memory from long-lived plasma cells that produce antibodies and memory B cells that can rapidly respond upon an encounter with the pathogen or its variants. The COVID-19 pandemic and rapid deployment of effective vaccines have provided an unprecedented opportunity to study the immune response to a new yet rapidly evolving pathogen. Here we review the scientific literature and our efforts to understand antibody and B-cell responses to SARS-CoV-2 vaccines, the effect of SARS-CoV-2 infection on both primary and secondary immune responses, and how repeated exposures may impact outcomes.

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Vol. 7 No. 2: Volume 7, Number 2
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