Historical Highlight: Three Seminal Articles Relating to the Recognition of Protein Antigens by Antibodies

Neil Greenspan; Emily Kukan

doi:10.20411/pai.v11i2.1091

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Published: Sep 30, 2026

DOI: https://doi.org/10.20411/pai.v11i2.1091

Keywords:

Complementarity, Hypervariable Regions, Complementarity Determining Regions, Epitope, Paratope

Neil S. Greenspan

Case Western Reserve University

Emily N. Kukan

Case Western Reserve University

Abstract

Beginning with this installment, the Pathogens and Immunity Historical Highlight series will focus, at least in some instances, on important themes in immunology, infectious disease, and microbiology by summarizing the contributions of a small and highly selected sampling of foundational articles instead of discussing just one landmark publication. By contrast, the first 2 installments were devoted to single studies that offered insights fundamental to all 3 of the above-cited disciplines and many other biomedical fields.

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Vol. 11 No. 2 (2026): Volume 11, Number 2

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Commentaries

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