Hurdles to the Development of Effective HBV Immunotherapies and HCV Vaccines

Almudena Torres-Cornejo, Georg M. Lauer

Abstract


Chronic infections with HBV and HCV continue to be major public health
problems, with hundreds of millions of people infected worldwide; this is
despite the availability of both an effective prophylactic HBV vaccine for
more than 3 decades and potent direct antivirals for HBV and, more
recently, HCV infection. Consequently, development of HBV immunotherapies
and prophylactic HCV vaccines remains extremely urgent, but limited funding
and significant gaps in our understanding of the correlates of immune
protection pose serious hurdles for the development of novel immune-based
interventions. Here we discuss immunological questions related to HBV and
HCV, some shared and some pertinent to only 1 of the viruses, that should
be addressed for the rational design of HBV immunotherapies and HCV
vaccines.


Keywords


hepatitis-B, hepatitis-C, research funding, immune response, T cell, antibodies, vaccine, immunotherapy

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